MYCN-regulated miRNAs Inhibit Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma
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Running Title: Dickkopf-3 Regulating miRNAs in Neuroblastoma Authors with affiliations: Bjørn Helge Haug, Jørn Remi Henriksen, Jochen Buechner, Per Kogner, Tommy Martinsson, Trond Flægstad, Baldur Sveinbjørnsson, Christer Einvik Department of Pediatrics, University Hospital of North-Norway, 9038 Tromsø, Norway Pediatric Research Group, Department of Clinical Biology, Faculty of Health Science, University of Tromsø, 9037 Tromsø, Norway Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden Department of Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden Division of Immunology, Department of Medical Biology, Faculty of Health Science, University of Tromsø, 9037 Tromsø, Norway
منابع مشابه
MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma.
The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the DKK family of Wnt regulators. It functions as a tumor suppressor in a range of cancers, including neuroblastoma. MYCN was recently found to downregulate DKK3 mRNA. In this study, we show that MYCN knockdown in MYCN...
متن کاملDickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma.
Neuroblastoma (NB) is a paediatric tumour with a remarkable diverse clinical behaviour. Approximately half of the high stage aggressive tumours are characterized by MYCN gene amplification but our understanding of the role of MYCN in NB oncogenesis is incomplete. Previous studies have shown that MYCN expression is inversely correlated with expression of Dickkopf-3 (DKK3), a gene encoding an ext...
متن کاملmiRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs
BACKGROUND MicroRNAs are small molecules which regulate gene expression post-transcriptionally and aberrant expression of several miRNAs is associated with neuroblastoma, a childhood cancer arising from precursor cells of the sympathetic nervous system. Amplification of the MYCN transcription factor characterizes the most clinically aggressive subtype of this disease, and although alteration of...
متن کاملp53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance
Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. MYCN is a proto-oncogene implicated to be directly involved in neuroblastoma development. Amplification of MYCN is associated with ra...
متن کاملRole of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas
Neuroblastoma (NB), a tumor of the sympathetic nervous system, is the most common extracranial solid tumor of childhood. We and others have identified distinct patterns of genomic change that underlie diverse clinical behaviors, from spontaneous regression to relentless progression. We first identified CHD5 as a tumor suppressor gene that is frequently deleted in NBs. Mutation of the remaining ...
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تاریخ انتشار 2011